1268264-10-3
1268264-10-3 structure
- Name: SOMG-833
- Chemical Name: SOMG-833
- CAS Number: 1268264-10-3
- Molecular Formula: C22H22F3N5O2
- Molecular Weight: 445.446
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
- Create Date: 2020-01-12 14:32:50
- Modify Date: 2023-10-17 17:38:47
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A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo.
| Name | SOMG-833 |
|---|
| Description | A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo. |
|---|---|
| References | References 1. Zhang HT, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45. View Related Products by Target c-Met (HGFR) |
| Molecular Formula | C22H22F3N5O2 |
|---|---|
| Molecular Weight | 445.446 |