Dapaconazole

Modify Date: 2024-01-09 17:52:24

Use of Dapaconazole

Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM[1].

Name	dapaconazole
Synonym	More Synonyms

Description	Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Target	Cytochrome P450 (CYP26):1.4 μM (IC50)
In Vitro	Dapaconazole inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 ± 0.3 μM[1].
In Vivo	Dapaconazole (20 mg/kg; p.o.) shows that the bioavailability is 97.3 %[1]. Animal Model: Male beagle dogs[1] Dosage: 20 mg/kg (Pharmacokinetic Analysis) Administration: P.o. Result: Showed that the bioavailability was 97.3 %.
References	[1]. Juliana SP, et al. Pharmacokinetics of Dapaconazole, A Novel Antifungal Agent, in Beagle Dogs and Inhibition of Cytochrome P450 Family 51. J Eur Acad Dermatol Venereol. 2018 Jun 10.

1-[2-(2,4-Dichlorophenyl)-2-{[4-(trifluoromethyl)benzyl]oxy}ethyl]-1H-imidazole

dapaconazole

H2976538CX

1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[[4-(trifluoromethyl)phenyl]methoxy]ethyl]-

UNII:H2976538CX

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Price: ￥3000/5 mg

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