1269726-67-1

1269726-67-1 structure

Name: Dapaconazole
Chemical Name: dapaconazole
CAS Number: 1269726-67-1
Molecular Formula: C₁₉H₁₅Cl₂F₃N₂O
Molecular Weight: 415.236
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2018-10-17 17:40:47
Modify Date: 2024-01-09 17:52:24
Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM[1].

Name	dapaconazole
Synonyms	1-[2-(2,4-Dichlorophenyl)-2-{[4-(trifluoromethyl)benzyl]oxy}ethyl]-1H-imidazole dapaconazole H2976538CX 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[[4-(trifluoromethyl)phenyl]methoxy]ethyl]- UNII:H2976538CX

Description	Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Target	Cytochrome P450 (CYP26):1.4 μM (IC50)
In Vitro	Dapaconazole inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 ± 0.3 μM[1].
In Vivo	Dapaconazole (20 mg/kg; p.o.) shows that the bioavailability is 97.3 %[1]. Animal Model: Male beagle dogs[1] Dosage: 20 mg/kg (Pharmacokinetic Analysis) Administration: P.o. Result: Showed that the bioavailability was 97.3 %.
References	[1]. Juliana SP, et al. Pharmacokinetics of Dapaconazole, A Novel Antifungal Agent, in Beagle Dogs and Inhibition of Cytochrome P450 Family 51. J Eur Acad Dermatol Venereol. 2018 Jun 10.