PI3K-IN-8q
Modify Date: 2023-01-15 19:21:51
PI3K-IN-8q structure
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Common Name | PI3K-IN-8q | ||
|---|---|---|---|---|
| CAS Number | 1280204-67-2 | Molecular Weight | 446.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23FN8O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3K-IN-8qPI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively; exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM; has promising in vivo PK data; orally bioavailable. |
| Name | PI3K-IN-8q |
|---|
| Description | PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively; exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM; has promising in vivo PK data; orally bioavailable. |
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| References | References 1. Martínez González S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2536-2543. View Related Products by Target PI3K |
| Molecular Formula | C23H23FN8O |
|---|---|
| Molecular Weight | 446.49 |