MCH(human, mouse, rat)

Modify Date: 2024-01-02 20:11:16

MCH(human, mouse, rat) structure	Common Name	MCH(human, mouse, rat)
	CAS Number	128315-56-0	Molecular Weight	2386.84000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀₅H₁₆₀N₃₀O₂₆S₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of MCH(human, mouse, rat)

MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively[1].

Name	Melanin Concentrating Hormone rat
Synonym	More Synonyms

Description	MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24) Research Areas >> Neurological Disease
Target	Binding IC50: 0.3 nM (MCH1R) IC50: 1.5 nM (MCH1R)[1]
References	[1]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.

Molecular Formula	C₁₀₅H₁₆₀N₃₀O₂₆S₄
Molecular Weight	2386.84000
Exact Mass	2385.10000
PSA	1018.94000
LogP	6.54720
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T+
RIDADR	NONH for all modes of transport
WGK Germany	3

The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.

Nat. Cell Biol. 12 , 267-271, (1999)

Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we i...

Molecular characterization of the melanin-concentrating-hormone receptor.

Nature 400 , 265-269, (1999)

Orphan G-protein-coupled receptors (GPCRs) are cloned proteins with structural characteristics common to the GPCRs but that bind unidentified ligands. Orphan GPCRs have been used as targets to identif...

Investigation of the feeding effects of melanin concentrating hormone on food intake--action independent of galanin and the melanocortin receptors.

Brain Res. 846 , 164-170, (1999)

Melanin concentrating hormone (MCH) is recognised as a hypothalamic appetite stimulant. The mechanism of action of MCH is undetermined largely due to lack of identification of hypothalamic MCH recepto...

MFCD00080193

Melanin Concentrating Hormone,human,mouse

Melanin concentrating hormone,human,mouse,rat