BI99179

Modify Date: 2024-04-05 15:59:07

BI99179 structure	Common Name	BI99179
	CAS Number	1291779-76-4	Molecular Weight	391.463
	Density	1.3±0.1 g/cm3	Boiling Point	603.1±55.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₅N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	318.5±31.5 °C

Use of BI99179

BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM; demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM; BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target.

Name	(1R,3S)-N-[4-(1,3-Benzoxazol-2-yl)phenyl]-N-methyl-3-(propionylamino)cyclopentanecarboxamide
Synonym	More Synonyms

Description	BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM; demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM; BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Metabolic Disease
Target	IC50: 79 nM (FAS)[1]
In Vitro	BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1].
In Vivo	BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg)with half life (t1/2) of 3.0 h[1].
References	[1]. Kley JT, et al. Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.

Density	1.3±0.1 g/cm3
Boiling Point	603.1±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₅N₃O₃
Molecular Weight	391.463
Flash Point	318.5±31.5 °C
Exact Mass	391.189606
LogP	3.12
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.633

Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)-

(1R,3S)-N-[4-(1,3-Benzoxazol-2-yl)phenyl]-N-methyl-3-(propionylamino)cyclopentanecarboxamide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BI 99179
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BI-99179
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: BI-99179
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

BI99179 suppliers

BI99179 price

BI99179

Use of BI99179

Names

BI99179 Biological Activity

Chemical & Physical Properties

Synonyms