Bizelesin
Bizelesin structure
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Common Name | Bizelesin | ||
|---|---|---|---|---|
| CAS Number | 129655-21-6 | Molecular Weight | 815.70300 | |
| Density | 1.604g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C43H36Cl2N8O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BizelesinBizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1]. |
| Name | 1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea |
|---|---|
| Synonym | More Synonyms |
| Description | Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1]. |
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| Related Catalog | |
| In Vitro | Bizelesin (0-5 μM, 4 h)可以通过靶向人类癌细胞 CEM 细胞中富含 AT的 DNA 域，造成 DNA 特异性损伤，进而造成癌细胞损伤，具有潜在的癌症治疗潜力[1]。 Bizelesin (0-500 nM)在 BSC-1 细胞中，当浓度为 10 nM 时导致 50% 的 DNA 合成抑制，相比之下，浓度为 160 nM 时才抑制 50% RNA 合成，而浓度高达至 200 nM 时也没有观察到蛋白质合成的抑制[2]。 |
| References |
| Density | 1.604g/cm3 |
|---|---|
| Molecular Formula | C43H36Cl2N8O5 |
| Molecular Weight | 815.70300 |
| Exact Mass | 814.21900 |
| PSA | 185.37000 |
| LogP | 9.52540 |
| Index of Refraction | 1.856 |
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Bizelesin CAS#:129655-21-6 |
| Literature: Journal of the American Chemical Society, , vol. 113, # 23 p. 8994 - 8995 |
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Bizelesin CAS#:129655-21-6 |
| Literature: Journal of the American Chemical Society, , vol. 113, # 23 p. 8994 - 8995 |
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Bizelesin CAS#:129655-21-6 |
| Literature: Heterocycles, , vol. 45, # 12 p. 2303 - 2308 |
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Bizelesin CAS#:129655-21-6 |
| Literature: Heterocycles, , vol. 45, # 12 p. 2303 - 2308 |
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Bizelesin CAS#:129655-21-6 |
| Literature: Heterocycles, , vol. 45, # 12 p. 2303 - 2308 |
|
~%
Bizelesin CAS#:129655-21-6 |
| Literature: Heterocycles, , vol. 45, # 12 p. 2303 - 2308 |
|
~%
Bizelesin CAS#:129655-21-6 |
| Literature: Journal of the American Chemical Society, , vol. 113, # 23 p. 8994 - 8995 |
|
~%
Bizelesin CAS#:129655-21-6 |
| Literature: Heterocycles, , vol. 45, # 12 p. 2303 - 2308 |
![(S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole hydrochloride structure](https://image.chemsrc.com/caspic/081/110314-54-0.png)
![(S)-1,6-dihydro-1-(hydroxymethyl)-8-methyl-5-(phenylmethoxy)-benzo[1,2-b:4,3-b']dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester structure](https://image.chemsrc.com/caspic/082/112836-67-6.png)
![(S)-1-(chloromethyl)-1,6-dihydro-8-methyl-5-(phenylmethoxy)-benzo[1,2-b:4,3-b']dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester structure](https://image.chemsrc.com/caspic/243/110314-50-6.png)
![(S)-6-tert-butyl 1-methyl 8-(acetoxymethyl)-4-(benzyloxy)-7,8-dihydropyrrolo[3,2-e]indole-1,6(3H)-dicarboxylate structure](https://image.chemsrc.com/caspic/424/176685-39-5.png)
![(1S)-3-[(tert-butyloxy)carbonyl]-1-(chloromethyl)-5-hydroxy-8-methyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole structure](https://image.chemsrc.com/caspic/205/110314-51-7.png)
| Benzo(1,2-b:4,3-b')dipyrrol-4-ol,6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*)) |
| U-77,779 |
| BIZELESIN |
| Bizelesin (USAN/INN) |