Diatrizoate Meglumine

Modify Date: 2024-01-02 01:26:43

Diatrizoate Meglumine Structure
Diatrizoate Meglumine structure
 Common Name Diatrizoate Meglumine
CAS Number 131-49-7 Molecular Weight 809.127
Density 1.9465 (estimate) Boiling Point 614.1ºC at 760mmHg
Molecular Formula C18H26I3N3O9 Melting Point 189-193° (dec)
MSDS Chinese USA Flash Point N/A

 Use of Diatrizoate Meglumine


Diatrizoate meglumine is the meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography.

 Names

Name meglumine amidotrizoate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.9465 (estimate)
Boiling Point 614.1ºC at 760mmHg
Melting Point 189-193° (dec)
Molecular Formula C18H26I3N3O9
Molecular Weight 809.127
Exact Mass 808.880310
PSA 215.66000
LogP 1.44700
Vapour Pressure 6.19E-16mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LZ4315000
CHEMICAL NAME :
Glucitol, 1-deoxy-1-(methylamino)-, 3,5-diacetamido-2,4,6-triiodobenzoate (salt), D-
CAS REGISTRY NUMBER :
131-49-7
LAST UPDATED :
199710
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C11-H9-I3-N2-O4.C7-H17-N-O5
MOLECULAR WEIGHT :
809.17
WISWESSER LINE NOTATION :
1VMR BI DI FI CVQ EMV1 &Q1YQYQYQYQ1M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
214 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli Kidney, Ureter, Bladder - interstitial nephritis Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,392,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14565 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.126- 1976- Volume(issue)/page/year: 142,619,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
44504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.126- 1976- Volume(issue)/page/year: 142,619,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
19500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 26,921,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,32,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,595,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81430 No. of Facilities: 86 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1252 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81430 No. of Facilities: 1221 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 27048 (estimated) No. of Female Employees: 17626 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
RTECS LZ4315000

 Articles39

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In vitro immunomodulatory effects of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on the cellular immune response.

Immunopharmacol. Immunotoxicol. 36(2) , 150-7, (2014)

The aim of this study was to determine the immunomodulatory activity of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide in vitro. This compound was used for the synthesis of a series of 5-amino-...

A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)

The effect of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on lymphocyte subsets and humoral immune response in SRBC-immunized mice.

Immunopharmacol. Immunotoxicol. 37(2) , 148-57, (2015)

5-Amino-3-methyl-4-isoxazolecarboxylic acid hydrazide is a non-cytotoxic synthetic isoxazole derivative with considerable immunomodulatory properties demonstrated in in vitro experiments. The aim of t...

 Synonyms

Megluminamidotrizoat
Diatrizoic Acid Methylglucamine
MFCD00069632
3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid - (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:1)
Meglumin-diazetrizoat
1-deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate
3,5-diacetamido-2,4,6-triiodobenzoic acid,(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, compd. with D-glucitol, 1-deoxy-1-(methylamino)- (1:1)
Diatrizoate methylglucamine
Diatrizoate Meglumine
Hypaque meglumine
Renograffin
Meglumine amidotrizoate
Renografin M-76
Unipaque
Reno M-Dip
3,5-Diacetamido-2,4,6-triiodobenzoic acid - 1-deoxy-1-(methylamino)-D-glucitol (1:1)
Angiografin
D-Glucitol, 1-deoxy-1-(methylamino)-, 3,5-bis(acetylamino)-2,4,6-triiodobenzoate (salt)
Renurix
Renografin
Methylglucamine diatrizoate
acide 3,5-bis(acétylamino)-2,4,6-triiodobenzoïque - (2R,3R,4R,5S)-6-(méthylamino)hexane-1,2,3,4,5-pentol (1:1)
3,5-Bis(acetylamino)-2,4,6-triiodbenzolcarbonsäure--(2R,3R,4R,5S)-6-(methylamino)hexan-1,2,3,4,5-pentol(1:1)
N-Methyl-D-glucamine diatrizoate
Amidotrizoate meglumine
3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid compd. with 1-Deoxy-1-(methylamino)-D-glucitol (1:1)
Urografin 76
Urovist
EINECS 205-024-7
Cystografin
ioxeol
Meglumin-diatrizoat
meglumine diatriazoate
3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid - 1-deoxy-1-(methylamino)-D-glucitol (1:1)
meglumine diatrizoate
Triombrast
Verografin
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