Tafamidis meglumine
Modify Date: 2024-01-04 09:56:30
Tafamidis meglumine structure
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Common Name | Tafamidis meglumine | ||
|---|---|---|---|---|
| CAS Number | 951395-08-7 | Molecular Weight | 503.33000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H24Cl2N2O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tafamidis meglumineTafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis[1]. |
| Name | tafamidis meglumine |
|---|---|
| Synonym | More Synonyms |
| Description | Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis[1]. |
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| Related Catalog | |
| Target |
EC50: 2.7-3.2 μM (TTR)[1] |
| In Vitro | Tafamidis binds selectively and with negative cooperativity (Kds ∼2 nM and ∼200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR[1]. Tafamidis (0-7.2 μM) dose-dependently inhibits WT-TTR amyloidogenesis after treatment for 72 hours at a pH of 4.4-4.5[1]. |
| References |
| Molecular Formula | C21H24Cl2N2O8 |
|---|---|
| Molecular Weight | 503.33000 |
| Exact Mass | 502.09100 |
| PSA | 176.51000 |
| LogP | 1.53240 |
| Storage condition | 2-8℃ |
| Vyndaqel |
| UNII-ZU7CF08A1A |
| Tafamidis meglumine |
| 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid,(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol |
| ZU7CF08A1A |
| Fx-1006A |