Oxybenzone

Modify Date: 2024-01-02 14:01:13

Oxybenzone Structure
Oxybenzone structure
 Common Name Oxybenzone
CAS Number 131-57-7 Molecular Weight 228.243
Density 1.2±0.1 g/cm3 Boiling Point 370.3±27.0 °C at 760 mmHg
Molecular Formula C14H12O3 Melting Point 62-64 °C(lit.)
MSDS Chinese USA Flash Point 140.5±17.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Oxybenzone


Oxybenzone(Eusolex 4360; Escalol 567) is an organic compound used in sunscreens; provides broad-spectrum ultraviolet coverage, including UVB and short-wave UVA rays.

 Names

Name 2-Hydroxy-4-methoxybenzophenone
Synonym More Synonyms

 Oxybenzone Biological Activity

Description Oxybenzone(Eusolex 4360; Escalol 567) is an organic compound used in sunscreens; provides broad-spectrum ultraviolet coverage, including UVB and short-wave UVA rays.
Related Catalog
References

[1]. Oxybenzone, From Wikipedia

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 370.3±27.0 °C at 760 mmHg
Melting Point 62-64 °C(lit.)
Molecular Formula C14H12O3
Molecular Weight 228.243
Flash Point 140.5±17.2 °C
Exact Mass 228.078644
PSA 46.53000
LogP 3.64
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.596
Storage condition 2-8°C
Water Solubility <0.1 g/100 mL at 20 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ1575000
CHEMICAL NAME :
Benzophenone, 2-hydroxy-4-methoxy-
CAS REGISTRY NUMBER :
131-57-7
BEILSTEIN REFERENCE NO. :
1913145
LAST UPDATED :
199712
DATA ITEMS CITED :
23
MOLECULAR FORMULA :
C14-H12-O3
MOLECULAR WEIGHT :
228.26
WISWESSER LINE NOTATION :
1OR CQ DVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
189 gm/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8246 mg/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
164 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in platelet count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in other cell count (unspecified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
104 gm/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
544 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
45 gm/kg
SEX/DURATION :
female 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
54 gm/kg
SEX/DURATION :
male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
333 gm/kg
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
297 gm/kg
SEX/DURATION :
female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1268 gm/kg
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1687 gm/kg
SEX/DURATION :
female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
5915 mg/kg
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3220 No. of Facilities: 51 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 549 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3220 No. of Facilities: 1336 (estimated) No. of Industries: 21 No. of Occupations: 18 No. of Employees: 27518 (estimated) No. of Female Employees: 8664 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS DJ1575000
Packaging Group II; III
Hazard Class 4.1
HS Code 29145000

 Synthetic Route

 Customs

HS Code 2914502000
Summary 2914502000 (2-hydroxy-4-methoxyphenyl)(phenyl)methanone。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%

 Articles40

More Articles
Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters.

Int. J. Pharm. 476(1-2) , 160-3, (2015)

Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesti...
Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry (APGC-ToF-MS) for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction (SBSE).

Anal. Chim. Acta 851 , 1-13, (2014)

This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrin...
Determination of nine environmental phenols in urine by ultra-high-performance liquid chromatography-tandem mass spectrometry.

J. Anal. Toxicol. 36(9) , 608-15, (2012)

A method was developed to determine nine environmental phenols, including bisphenol A, 2,3,4-trichlorophenol, 2,4,5-trichlorophenol, pentachlorophenol, triclosan (2,4,4'-trichloro-2'-hydroxyphenylethe...

 Synonyms

Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-
Benzophenone, 2-hydroxy-4-methoxy-
(2-Hydroxy-4-methoxyphenyl)(phenyl)methanone
BENZOPHENONE-3
Uvinul 3040
2-hydroxy-4-methoxyphenyl phenyl ketone
EINECS 205-031-5
Benzophenone-3 (Bp-3)
Uvinul M-40
2-hydroxy-4-methoxy benzophenone
oxybenzone
MFCD00008387
2-Hydroxy-4-methoxybenzophenone
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  • Product Name: Oxybenzone
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  • Purity: 98.0%
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Related Compounds: More...
Oxybenzone-d5
1219798-54-5
Chemsrc provides Oxybenzone(CAS#:131-57-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Oxybenzone are included as well.>> amp version: Oxybenzone

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