VBY-825
Modify Date: 2024-01-09 12:15:06
VBY-825 structure
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Common Name | VBY-825 | ||
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| CAS Number | 1310340-58-9 | Molecular Weight | 535.55200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H29F4N3O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VBY-825VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.IC50 value: Target: 130/250/250/330/2.3/4.7 nM(Ki for cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F) [1]VBY-825 is a potent inhibitor of the assayed cathepsins and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines. |
| Name | (S)-N-cyclopropyl-3-((R)-3-(cyclopropylmethylsulfonyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamido)-2-oxopentanamide |
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| Synonym | More Synonyms |
| Description | VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.IC50 value: Target: 130/250/250/330/2.3/4.7 nM(Ki for cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F) [1]VBY-825 is a potent inhibitor of the assayed cathepsins and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines. |
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| Related Catalog | |
| References |
| Molecular Formula | C23H29F4N3O5S |
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| Molecular Weight | 535.55200 |
| Exact Mass | 535.17600 |
| PSA | 129.82000 |
| LogP | 4.20810 |
| Storage condition | 2-8℃ |
| VBY-825 |