NSC 624206

Modify Date: 2024-01-05 17:35:05

NSC 624206 structure	Common Name	NSC 624206
	CAS Number	13116-77-3	Molecular Weight	410.508
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₃₃Cl₂NS₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NSC 624206

NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].

Name	N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride
Synonym	More Synonyms

Description	NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	IC50: ~9 μM (ubiquitin E1)[1]
In Vitro	NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1]. NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1]. NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1]. Western Blot Analysis[1] Cell Line: Kip16 cells Concentration: 10 nM-10 μM Incubation Time: 24 hours Result: Induced accumulation of p27.
References	[1]. Dana Ungermannova, et al. Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen . 2012 Apr;17(4):421-34.

Molecular Formula	C₁₉H₃₃Cl₂NS₂
Molecular Weight	410.508
Exact Mass	409.143158

Decylamine, N-(2-((p-chlorobenzyl)dithio)ethyl)-, hydrochloride

MFCD01736096

1-Decanamine, N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-, hydrochloride (1:1)

N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride

N-(2-((4-Chlorobenzyl)dithio)ethyl)-1-decanamine hydrochloride

N-{2-[(4-Chlorobenzyl)disulfanyl]ethyl}-1-decanamine hydrochloride (1:1)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NSC 624206
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: NSC-624206
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: NSC-624206
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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