NSC 624206
Modify Date: 2024-01-05 17:35:05
NSC 624206 structure
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Common Name | NSC 624206 | ||
|---|---|---|---|---|
| CAS Number | 13116-77-3 | Molecular Weight | 410.508 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H33Cl2NS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NSC 624206NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1]. |
| Name | N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1]. |
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| Related Catalog | |
| Target |
IC50: ~9 μM (ubiquitin E1)[1] |
| In Vitro | NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1]. NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1]. NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1]. Western Blot Analysis[1] Cell Line: Kip16 cells Concentration: 10 nM-10 μM Incubation Time: 24 hours Result: Induced accumulation of p27. |
| References |
| Molecular Formula | C19H33Cl2NS2 |
|---|---|
| Molecular Weight | 410.508 |
| Exact Mass | 409.143158 |
| Decylamine, N-(2-((p-chlorobenzyl)dithio)ethyl)-, hydrochloride |
| MFCD01736096 |
| 1-Decanamine, N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-, hydrochloride (1:1) |
| N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride |
| N-(2-((4-Chlorobenzyl)dithio)ethyl)-1-decanamine hydrochloride |
| N-{2-[(4-Chlorobenzyl)disulfanyl]ethyl}-1-decanamine hydrochloride (1:1) |