13116-77-3

13116-77-3 structure

Name: NSC 624206
Chemical Name: N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride
CAS Number: 13116-77-3
Molecular Formula: C₁₉H₃₃Cl₂NS₂
Molecular Weight: 410.508
Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
Create Date: 2018-07-20 22:40:09
Modify Date: 2024-01-05 17:35:05
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].

Name	N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride
Synonyms	Decylamine, N-(2-((p-chlorobenzyl)dithio)ethyl)-, hydrochloride MFCD01736096 1-Decanamine, N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-, hydrochloride (1:1) N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride N-(2-((4-Chlorobenzyl)dithio)ethyl)-1-decanamine hydrochloride N-{2-[(4-Chlorobenzyl)disulfanyl]ethyl}-1-decanamine hydrochloride (1:1)

Description	NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	IC50: ~9 μM (ubiquitin E1)[1]
In Vitro	NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1]. NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1]. NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1]. Western Blot Analysis[1] Cell Line: Kip16 cells Concentration: 10 nM-10 μM Incubation Time: 24 hours Result: Induced accumulation of p27.
References	[1]. Dana Ungermannova, et al. Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen . 2012 Apr;17(4):421-34.