TAK-659
Modify Date: 2024-01-10 19:55:58
TAK-659 structure
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Common Name | TAK-659 | ||
|---|---|---|---|---|
| CAS Number | 1312691-33-0 | Molecular Weight | 344.387 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 661.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H21FN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 354.0±31.5 °C | |
Use of TAK-659TAK-659 is a highly potent, selective, reversible and orally available inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM for SYK. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4]. |
| Name | 8QR88H79VX |
|---|---|
| Synonym | More Synonyms |
| Description | TAK-659 is a highly potent, selective, reversible and orally available inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM for SYK. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4]. |
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| Related Catalog | |
| Target |
IC50: 3.2 nM (Syk)[1] |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 661.7±55.0 °C at 760 mmHg |
| Molecular Formula | C17H21FN6O |
| Molecular Weight | 344.387 |
| Flash Point | 354.0±31.5 °C |
| Exact Mass | 344.176086 |
| LogP | 0.28 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.756 |
| Storage condition | 2-8°C |
| 6-{[(1R,2S)-2-Aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one |
| MFCD30829411 |
| 8QR88H79VX |
| 3H-Pyrrolo[3,4-c]pyridin-3-one, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)- |