Miransertib HCl
Modify Date: 2024-03-03 15:59:06
Miransertib HCl structure
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Common Name | Miransertib HCl | ||
|---|---|---|---|---|
| CAS Number | 1313883-00-9 | Molecular Weight | 468.981 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H25ClN6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Miransertib HClMiransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma. |
| Name | 3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1) |
|---|---|
| Synonym | More Synonyms |
| Molecular Formula | C27H25ClN6 |
|---|---|
| Molecular Weight | 468.981 |
| Exact Mass | 468.182922 |
| Storage condition | -20℃ |
| 3-{3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl}-2-pyridinamine hydrochloride (1:1) |
| MFCD31536778 |
| 2-Pyridinamine, 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-, hydrochloride (1:1) |