EPZ020411 HCl

Modify Date: 2025-08-22 14:15:45

EPZ020411 HCl Structure
EPZ020411 HCl structure
Common Name EPZ020411 HCl
CAS Number 1700663-41-7 Molecular Weight 442.594
Density 1.2±0.1 g/cm3 Boiling Point 619.2±55.0 °C at 760 mmHg
Molecular Formula C25H38N4O3 Melting Point N/A
MSDS N/A Flash Point 328.3±31.5 °C

 Use of EPZ020411 HCl


EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8.IC50 value: 10 nMTarget: PRMT6in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.

 Names

Name N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)-1,2-ethanediamine
Synonym More Synonyms

 EPZ020411 HCl Biological Activity

Description EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8.IC50 value: 10 nMTarget: PRMT6in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.
Related Catalog
References

[1]. Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 ToolCompound. ACS Med Chem Lett. 2015 Apr 6;6(6):655-659.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 619.2±55.0 °C at 760 mmHg
Molecular Formula C25H38N4O3
Molecular Weight 442.594
Flash Point 328.3±31.5 °C
Exact Mass 442.294403
LogP 1.92
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.579
Storage condition -20℃

 Synonyms

N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)-1,2-ethanediamine
1,2-Ethanediamine, N,N-dimethyl-N-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-
EPZ020411 HCl
EPZ020411
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