(2H10)-5H-Dibenzo[b,f]azepine-5-carboxamide

Modify Date: 2024-01-06 17:00:46

(2H10)-5H-Dibenzo[b,f]azepine-5-carboxamide structure	Common Name	(2H10)-5H-Dibenzo[b,f]azepine-5-carboxamide
	CAS Number	132183-78-9	Molecular Weight	246.330
	Density	1.3±0.1 g/cm3	Boiling Point	411.0±48.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂D₁₀N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	202.4±29.6 °C
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of (2H10)-5H-Dibenzo[b,f]azepine-5-carboxamide

Carbamazepine-D10 (CBZ-D10) is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2].

Name	1,2,3,4,5,6,7,8,9,10-decadeuteriobenzo[b][1]benzazepine-11-carboxamide
Synonym	More Synonyms

Description	Carbamazepine-D10 (CBZ-D10) is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2].
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In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [3]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53.

MSDS(Chinese)

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

(H)-5H-Dibenzo[b,f]azepine-5-carboxamide

5H-Dibenz[b,f]azepine-d-5-carboxamide