1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

Modify Date: 2024-01-30 17:08:20

1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine Structure
1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine structure
Common Name 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine
CAS Number 132834-58-3 Molecular Weight 231.21800
Density 1.253 g/cm3 Boiling Point 122 °C (2 mmHg)
Molecular Formula C10H12F3N3 Melting Point 43-46°C
MSDS N/A Flash Point 154.8ºC

 Names

Name 1-[5-(Trifluoromethyl)pyridin-2-yl]piperazine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.253 g/cm3
Boiling Point 122 °C (2 mmHg)
Melting Point 43-46°C
Molecular Formula C10H12F3N3
Molecular Weight 231.21800
Flash Point 154.8ºC
Exact Mass 231.09800
PSA 28.16000
LogP 1.90380
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.5
Storage condition 2-8°C

 MSDS

Name: 1-[5-(Trifluoromethyl)-2-pyridinyl]piperazine Material Safety Data Sheet
Synonym: None
CAS: 132834-58-3
Section 1 - Chemical Product MSDS Name:1-[5-(Trifluoromethyl)-2-pyridinyl]piperazine Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
132834-58-3 1-[5-(Trifluoromethyl)-2-pyridinyl]pip 98 unlisted
Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.
Potential Health Effects
Eye:
Causes eye irritation. May cause irreversible eye injury.
Skin:
Causes skin irritation. May cause skin burns. May be harmful if absorbed through the skin.
Ingestion:
May cause burns to the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 132834-58-3: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid or liquid
Color: pale yellow
Odor: amine-like
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 83 deg C @ 0.1mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H12F3N3
Molecular Weight: 231.22

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, acid chlorides, acid anhydrides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride gas.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 132834-58-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1-[5-(Trifluoromethyl)-2-pyridinyl]piperazine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 132834-58-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 132834-58-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 132834-58-3 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes C: Corrosive;
Risk Phrases R34
Safety Phrases S37/39-S26
HS Code 2933990090

 Synthetic Route

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1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine Structure

1-(5-Trifluorom...

CAS#:132834-58-3

Literature: US5912246 A1, ; US 5912246 A

~%

1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine Structure

1-(5-Trifluorom...

CAS#:132834-58-3

Literature: Tetrahedron Letters, , vol. 47, # 15 p. 2549 - 2552

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine
MFCD00114708
1-[5-(Trifluoromethyl)-2-pyridinyl]piperazine