Pravastatin-d3 (sodium salt)

Modify Date: 2024-01-12 17:44:16

Pravastatin-d3 (sodium salt) Structure
Pravastatin-d3 (sodium salt) structure
Common Name Pravastatin-d3 (sodium salt)
CAS Number 1329836-90-9 Molecular Weight 449.528
Density N/A Boiling Point N/A
Molecular Formula C23H32D3NaO7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pravastatin-d3 (sodium salt)


Pravastatin-d3 (CS-514-d3) sodium salt is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].

 Names

Name Pravastatin-d3 (sodium salt)
Synonym More Synonyms

 Pravastatin-d3 (sodium salt) Biological Activity

Description Pravastatin-d3 (CS-514-d3) sodium salt is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89.

 Chemical & Physical Properties

Molecular Formula C23H32D3NaO7
Molecular Weight 449.528
Exact Mass 449.246887

 Synonyms

1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-(methyl-d3)-1-oxobutoxy]-, sodium salt, (βR,δR,1S,2S,6S,8S,8aR)- (1:1)
Sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-(2H3)methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoate
Pravastatin-d3 (sodium salt)