ST 034307

Modify Date: 2024-01-04 21:46:06

ST 034307 Structure
ST 034307 structure
Common Name ST 034307
CAS Number 133406-29-8 Molecular Weight 297.95000
Density N/A Boiling Point N/A
Molecular Formula C10H4Cl4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ST 034307


ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.

 Names

Name 6-chloro-2-(trichloromethyl)-4H-chromen-4-one
Synonym More Synonyms

 ST 034307 Biological Activity

Description ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
Related Catalog
Target

IC50: 2.3 μM (AC1)[1]

In Vitro ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1[1].
In Vivo ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model[1].
Cell Assay Cell viability assays are conducted with HEK-AC1 cells following plating and compound incubation protocols identical to the procedures described in “cAMP accumulation in cells.” Cell viability is measured as a percentage of vehicle using 2% Triton X-100 as a control. The CellTiter-Glo Luminescent Cell Viability Assay kit from Promega is used to assess cell viability according to the manufacturer’s instructions. Luminescence counts are measured using Synergy 4.
References

[1]. Brust TF, et al. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci Signal. 2017 Feb 21;10(467).

 Chemical & Physical Properties

Molecular Formula C10H4Cl4O2
Molecular Weight 297.95000
Exact Mass 295.89700
PSA 30.21000
LogP 4.27310
Storage condition 2-8℃

 Synonyms

ST034307
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