ST-168
Modify Date: 2023-03-12 19:14:24
ST-168 structure
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Common Name | ST-168 | ||
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| CAS Number | 2126038-25-1 | Molecular Weight | 1010.762 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H44F5IN10O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ST-168ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively; exhibits improved inhibition toward PI3K isoforms compared to ST-162; demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model. |
| Name | ST-168 |
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| Description | ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively; exhibits improved inhibition toward PI3K isoforms compared to ST-162; demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model. |
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| References | References 1. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813. View Related Products by Target PI3K |
| Molecular Formula | C41H44F5IN10O7 |
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| Molecular Weight | 1010.762 |