Ceftibuten hydrate

Modify Date: 2024-01-13 18:41:52

Ceftibuten hydrate structure	Common Name	Ceftibuten hydrate
	CAS Number	1346153-47-6	Molecular Weight	428.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₆N₄O₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ceftibuten hydrate

Ceftibuten (Sch39720) hydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens[1][2].

Name	Ceftibuten hydrate

Description	Ceftibuten (Sch39720) hydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Ceftibuten (Sch39720) hydrate is highly active against Haemophilus influenza, Escherichia coli, Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes. Ceftibuten hydrate is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except βBacteroides fragilis. Ceftibuten hydrate is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml)[1].
In Vivo	Ceftibuten hydrate, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles[3].
References	[1]. Kearns GL, et al. Single-dose pharmacokinetics of ceftibuten (SCH 39720) in infants and children. Antimicrob Agents Chemother. 1991;35(10):2078-2084. [2]. Shawar R, et al. Comparative in vitro activity of ceftibuten (Sch 39720) against bacterial enteropathogens. Antimicrob Agents Chemother. 1989;33(5):781-784. [3]. Tamai I, et al. Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes. Biochem Pharmacol. 1994;48(5):881-888.

Molecular Formula	C₁₅H₁₆N₄O₇S₂
Molecular Weight	428.44