Deferiprone-d3

Modify Date: 2024-01-09 19:18:04

Deferiprone-d3 Structure
Deferiprone-d3 structure
Common Name Deferiprone-d3
CAS Number 1346601-82-8 Molecular Weight 142.170
Density 1.2±0.1 g/cm3 Boiling Point 232.7±40.0 °C at 760 mmHg
Molecular Formula C7H6D3NO2 Melting Point N/A
MSDS N/A Flash Point 94.5±27.3 °C

 Use of Deferiprone-d3


Deferiprone-d3 is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload[1][2].

 Names

Name Deferiprone-d3
Synonym More Synonyms

 Deferiprone-d3 Biological Activity

Description Deferiprone-d3 is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 232.7±40.0 °C at 760 mmHg
Molecular Formula C7H6D3NO2
Molecular Weight 142.170
Flash Point 94.5±27.3 °C
Exact Mass 142.082153
LogP -0.22
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.565

 Synonyms

3-Hydroxy-2-methyl-1-(2H3)methyl-4(1H)-pyridinone
4(1H)-Pyridinone, 3-hydroxy-2-methyl-1-(methyl-d3)-
DEFERIPRONE-D3