GS-5759

Modify Date: 2024-02-04 18:24:13

GS-5759 Structure
GS-5759 structure
Common Name GS-5759
CAS Number 1346653-91-5 Molecular Weight 850.95
Density N/A Boiling Point N/A
Molecular Formula C47H42N6O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GS-5759


A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM); inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM); also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts.

 Names

Name GS-5759

 GS-5759 Biological Activity

Description A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM); inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM); also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts.
References References 1. Tannheimer SL, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):85-93. 2. Joshi T, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):324-340. View Related Products by Target Phosphodiesterase (PDE)

 Chemical & Physical Properties

Molecular Formula C47H42N6O8S
Molecular Weight 850.95
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