1346653-91-5
1346653-91-5 structure
- Name: GS-5759
- Chemical Name: GS-5759
- CAS Number: 1346653-91-5
- Molecular Formula: C47H42N6O8S
- Molecular Weight: 850.95
- Create Date: 2020-01-19 14:49:15
- Modify Date: 2025-08-20 15:46:42
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A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM); inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM); also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts.
| Name | GS-5759 |
|---|
| Description | A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM); inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM); also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts. |
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| References | References 1. Tannheimer SL, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):85-93. 2. Joshi T, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):324-340. View Related Products by Target Phosphodiesterase (PDE) |
| Molecular Formula | C47H42N6O8S |
|---|---|
| Molecular Weight | 850.95 |