N-Phenyl-2-naphthylamine

Modify Date: 2024-01-05 14:08:53

N-Phenyl-2-naphthylamine Structure
N-Phenyl-2-naphthylamine structure
Common Name N-Phenyl-2-naphthylamine
CAS Number 135-88-6 Molecular Weight 219.281
Density 1.2±0.1 g/cm3 Boiling Point 395.5±0.0 °C at 760 mmHg
Molecular Formula C16H13N Melting Point 105-108 °C(lit.)
MSDS Chinese USA Flash Point 209.2±14.7 °C
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Warning

 Names

Name N-Phenyl-2-naphthylamine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 395.5±0.0 °C at 760 mmHg
Melting Point 105-108 °C(lit.)
Molecular Formula C16H13N
Molecular Weight 219.281
Flash Point 209.2±14.7 °C
Exact Mass 219.104797
PSA 12.03000
LogP 4.20
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.702
Storage condition -20°C
Stability Stable. Incompatible with oxidizing agents.
Water Solubility Insoluble.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QM4550000
CHEMICAL NAME :
2-Naphthylamine, N-phenyl-
CAS REGISTRY NUMBER :
135-88-6
BEILSTEIN REFERENCE NO. :
2211188
LAST UPDATED :
199712
DATA ITEMS CITED :
37
MOLECULAR FORMULA :
C16-H13-N
MOLECULAR WEIGHT :
219.30
WISWESSER LINE NOTATION :
L66J CMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8730 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8700 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Lungs, Thorax, or Respiration - acute pulmonary edema Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1450 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
19 gm/kg/19D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 gm/kg/30D-I
TOXIC EFFECTS :
Liver - liver function tests impaired Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
182 gm/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36400 mg/kg/1Y-I
TOXIC EFFECTS :
Liver - liver function tests impaired Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - proteinuria
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
437 gm/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
433 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
208 gm/kg/97W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
464 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
264 gm/kg/99W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17280 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 23(9),57,1979 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,325,1978 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,325,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,318,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Carcinogen JAN 1993 OEL-BELGIUM;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO N-PHENYL-beta-NAPHTHYLAMINE-air:CA lowest concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80313 No. of Facilities: 751 (estimated) No. of Industries: 15 No. of Occupations: 32 No. of Employees: 16148 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80313 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1356 (estimated) No. of Female Employees: 41 (estimated)

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Warning
Hazard Statements H315-H317-H319-H351-H411
Precautionary Statements P273-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn,N
Risk Phrases R36/38;R40;R43;R51/53
Safety Phrases S22-S24/25-S61-S36/37-S26
RIDADR 3077
WGK Germany 2
RTECS QM4550000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2921499090

 Synthetic Route

 Customs

HS Code 2921499090
Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles26

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Dephenylation of the rubber chemical N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine: a classical problem revisited.

Crit. Rev. Toxicol. 37(7) , 553-66, (2007)

N-phenyl-2-naphthylamine (PBNA) represents an example of a suspected carcinogen that is found negative in mutagenicity and clastogenicity testing as well as in long-term animal carcinogenicity bioassa...

 Synonyms

N-Phenyl-2-naphthylamine
2-Naphthalenamine, N-phenyl-
MFCD00004052
N-(2-Naphthyl)aniline
N-Phenyl-2-naphthalenamine
2-Anilinonaphthalene
N-phenylnaphthalen-2-amine
EINECS 205-223-9
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