N-Acetyl-L-farnesylcysteine
N-Acetyl-L-farnesylcysteine structure
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Common Name | N-Acetyl-L-farnesylcysteine | ||
|---|---|---|---|---|
| CAS Number | 135304-07-3 | Molecular Weight | 367.546 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 566.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H33NO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 296.1±30.1 °C | |
Use of N-Acetyl-L-farnesylcysteineArazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site[1]. |
| Name | Ac-Cys(farnesyl)-OH |
|---|---|
| Synonym | More Synonyms |
| Description | Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell[1]. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell[1]. |
| In Vivo | Arazine (AFC) (2,000 μg/20 μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12 μg/20 μl[1]. Animal Model: TPA-induced ear acute inflammation in mouse[1] Dosage: 2000 μg/20 μl Administration: 2000 μg/20 μl; Applied on ear Result: Inhibited ear edema, as measured by ear weight. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 566.1±50.0 °C at 760 mmHg |
| Molecular Formula | C20H33NO3S |
| Molecular Weight | 367.546 |
| Flash Point | 296.1±30.1 °C |
| Exact Mass | 367.218109 |
| PSA | 91.70000 |
| LogP | 5.86 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.520 |
| Storage condition | -15°C |
| HS Code | 2930909090 |
|---|
|
~82%
N-Acetyl-L-farn... CAS#:135304-07-3 |
| Literature: Journal of the American Chemical Society, , vol. 123, # 19 p. 4373 - 4381 |
|
~50%
N-Acetyl-L-farn... CAS#:135304-07-3 |
| Literature: Journal of the American Chemical Society, , vol. 114, # 10 p. 3966 - 3973 |
|
~97%
N-Acetyl-L-farn... CAS#:135304-07-3 |
| Literature: Tetrahedron Letters, , vol. 42, # 10 p. 1859 - 1861 |
|
~%
N-Acetyl-L-farn... CAS#:135304-07-3 |
| Literature: Journal of the American Chemical Society, , vol. 123, # 19 p. 4373 - 4381 |
|
~%
N-Acetyl-L-farn... CAS#:135304-07-3 |
| Literature: Journal of the American Chemical Society, , vol. 123, # 19 p. 4373 - 4381 |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| L-Cysteine, N-acetyl-S-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]- |
| N-Acetyl-S-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-L-cysteine |
| N-Acetylfarnesylcysteine |
| N-acetyl-S-farnesyl-L-Cysteine |
| N-acetyl-S-farnesylcysteine |
| Arazine |
| N-Acetyl-S-trans,trans-farnesyl-L-cysteine |
| N-AFC |
| afc |