trans-Ned 19

Modify Date: 2024-01-06 18:12:18

trans-Ned 19 Structure
trans-Ned 19 structure
Common Name trans-Ned 19
CAS Number 1354235-96-3 Molecular Weight 514.59100
Density N/A Boiling Point N/A
Molecular Formula C30H31FN4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of trans-Ned 19


trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1].

 Names

Name (1R,3S)-1-(3-{[4-(2-Fluorophenyl)-1-piperazinyl]methyl}-4-methoxy phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid

 trans-Ned 19 Biological Activity

Description trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1].
Related Catalog
Target

Ca2+

References

[1]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438.

 Chemical & Physical Properties

Molecular Formula C30H31FN4O3
Molecular Weight 514.59100
Exact Mass 514.23800
PSA 80.83000
LogP 4.65780
Storage condition -20°C
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