SPP 86

Modify Date: 2024-01-04 21:01:25

SPP 86 Structure
SPP 86 structure
Common Name SPP 86
CAS Number 1357349-91-7 Molecular Weight 277.32
Density N/A Boiling Point N/A
Molecular Formula C16H15N5 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of SPP 86


SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 selectively inhibits RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines[1].

 Names

Name SPP-86

 SPP 86 Biological Activity

Description SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 selectively inhibits RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines[1].
Related Catalog
Target

IC50: 8 nM (RET)[1].

References

[1]. Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.

 Chemical & Physical Properties

Molecular Formula C16H15N5
Molecular Weight 277.32

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport
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