AMG-1694

Modify Date: 2025-08-25 10:56:26

AMG-1694 Structure
AMG-1694 structure
 Common Name AMG-1694
CAS Number 1361217-07-3 Molecular Weight 533.63
Density N/A Boiling Point N/A
Molecular Formula C23H30F3N3O4S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AMG-1694


AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].

 Names

Name AMG-1694

 AMG-1694 Biological Activity

Description AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].
Related Catalog
Target

IC50: 7 nM (GK-GKRP)[1]

In Vitro AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020 μM in the presence of GKRP[1].
References

[1]. Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.

 Chemical & Physical Properties

Molecular Formula C23H30F3N3O4S2
Molecular Weight 533.63
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Chemsrc provides AMG-1694(CAS#:1361217-07-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AMG-1694 are included as well.>> amp version: AMG-1694

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