(R)-(+)-Dimethindene maleate
Modify Date: 2024-07-22 08:14:41
(R)-(+)-Dimethindene maleate structure
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Common Name | (R)-(+)-Dimethindene maleate | ||
|---|---|---|---|---|
| CAS Number | 136152-64-2 | Molecular Weight | 408.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H28N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (R)-(+)-Dimethindene maleate(R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs[1]. |
| Name | (R)-(+)-Dimethindene maleate |
|---|
| Description | (R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs[1]. |
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| Related Catalog | |
| Target |
H1 Receptor:7.7 (pA2) |
| In Vitro | (R)-(+)-Dimethindene maleate possesses membrane-stabilising effect[1]. |
| In Vivo | (R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED50 of 2.73 mg/kg in pigs[1]. Animal Model: Male guinea-pigs[1] Dosage: 10 mL/kg Administration: Oral gavage, once Result: The ED50-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED50-value was found to be >31.6mg/kg. The oral LD50-values was found to be 988 mg/kg. |
| References |
| Molecular Formula | C24H28N2O4 |
|---|---|
| Molecular Weight | 408.49 |