(R)-(+)-Dimethindene maleate

Modify Date: 2023-02-18 17:43:56

(R)-(+)-Dimethindene maleate structure	Common Name	(R)-(+)-Dimethindene maleate
	CAS Number	136152-64-2	Molecular Weight	408.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₈N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (R)-(+)-Dimethindene maleate

(R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs[1].

Name	(R)-(+)-Dimethindene maleate

Description	(R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor:7.7 (pA2)
In Vitro	(R)-(+)-Dimethindene maleate possesses membrane-stabilising effect[1].
In Vivo	(R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED50 of 2.73 mg/kg in pigs[1]. Animal Model: Male guinea-pigs[1] Dosage: 10 mL/kg Administration: Oral gavage, once Result: The ED50-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED50-value was found to be >31.6mg/kg. The oral LD50-values was found to be 988 mg/kg.
References	[1]. Leuschner J, et al. Evaluation of the dose-effect curves of dimethindene maleate enantiomers in various animal models. Agents and Actions, 1992, 36(2): C431-C433.

Molecular Formula	C₂₄H₂₈N₂O₄
Molecular Weight	408.49