136152-64-2
136152-64-2 structure
- Name: (R)-(+)-Dimethindene maleate
- Chemical Name: (R)-(+)-Dimethindene maleate
- CAS Number: 136152-64-2
- Molecular Formula: C24H28N2O4
- Molecular Weight: 408.49
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2022-11-04 13:09:29
- Modify Date: 2023-02-18 17:43:56
-
(R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs[1].
| Name | (R)-(+)-Dimethindene maleate |
|---|
| Description | (R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs[1]. |
|---|---|
| Related Catalog | |
| Target |
H1 Receptor:7.7 (pA2) |
| In Vitro | (R)-(+)-Dimethindene maleate possesses membrane-stabilising effect[1]. |
| In Vivo | (R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED50 of 2.73 mg/kg in pigs[1]. Animal Model: Male guinea-pigs[1] Dosage: 10 mL/kg Administration: Oral gavage, once Result: The ED50-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED50-value was found to be >31.6mg/kg. The oral LD50-values was found to be 988 mg/kg. |
| References |
| Molecular Formula | C24H28N2O4 |
|---|---|
| Molecular Weight | 408.49 |