RG-12915
Modify Date: 2024-01-09 17:31:12
RG-12915 structure
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Common Name | RG-12915 | ||
|---|---|---|---|---|
| CAS Number | 136174-04-4 | Molecular Weight | 360.878 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 462.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H25ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 233.6±28.7 °C | |
Use of RG-12915RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM. |
| Name | RG-12915 |
|---|---|
| Synonym | More Synonyms |
| Description | RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.16 nM (5-HT3)[1] |
| In Vitro | RG 12915 is a potent and selective displacer of binding of 5-hydroxytryptamine (5-HT3) binding sites (IC50 value = 0.16 nM), whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites with IC50 values less than 1 μM. |
| In Vivo | RG 12915 has a lower ED50 value (0.004 mg/kg) for attenuating cisplatin-induced emetic episodes in the ferret. RG 12915 (1 mg/kg, p.o.) is highly protective against cisplatin-induced emesis in the dog. RG 12915 has no significant gastroprokinetic activity in the same species[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 462.6±45.0 °C at 760 mmHg |
| Molecular Formula | C20H25ClN2O2 |
| Molecular Weight | 360.878 |
| Flash Point | 233.6±28.7 °C |
| Exact Mass | 360.160461 |
| LogP | 4.03 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.631 |
| Storage condition | 2-8℃ |
| 533O919MKO |
| 4-Dibenzofurancarboxamide, N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2-chloro-5a,6,7,8,9,9a-hexahydro-, (5aS,9aS)- |
| (5aS,9aS)-N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzo[b,d]furan-4-carboxamide |