YH 239-EE

Modify Date: 2025-08-25 13:18:07

YH 239-EE Structure
YH 239-EE structure
Common Name YH 239-EE
CAS Number 1364488-67-4 Molecular Weight 504.406
Density 1.3±0.1 g/cm3 Boiling Point 763.3±60.0 °C at 760 mmHg
Molecular Formula C25H27Cl2N3O4 Melting Point N/A
MSDS N/A Flash Point 415.4±32.9 °C

 Use of YH 239-EE


YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agentIC50 value:Target: MDM2/p53YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).

 Names

Name 1H-​Indole-​2-​carboxylic acid, 6-​chloro-​3-​[1-​[[(4-​chlorophenyl)​methyl]​formylamino]​-​2-​[(1,​1-​dimethylethyl)​amino]​-​2-​oxoethyl]​-​, ethyl ester
Synonym More Synonyms

 YH 239-EE Biological Activity

Description YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agentIC50 value:Target: MDM2/p53YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
Related Catalog
References

[1]. Huang Y, et al. Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem Biol. 2014 Mar 21;9(3):802-11.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 763.3±60.0 °C at 760 mmHg
Molecular Formula C25H27Cl2N3O4
Molecular Weight 504.406
Flash Point 415.4±32.9 °C
Exact Mass 503.137848
PSA 91.50000
LogP 4.85
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.615
Storage condition -20℃

 Synonyms

Ethyl 6-chloro-3-{1-[(4-chlorobenzyl)(formyl)amino]-2-[(2-methyl-2-propanyl)amino]-2-oxoethyl}-1H-indole-2-carboxylate
1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester
YH239-EE
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