Imatinib Impurity E
Modify Date: 2024-01-12 21:13:31
Imatinib Impurity E structure
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Common Name | Imatinib Impurity E | ||
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| CAS Number | 1365802-18-1 | Molecular Weight | 873.01700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C52H48N12O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Imatinib Impurity EImatinib Impurity E is the impurity of Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively[1][2][3][4]. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV[5]. |
| Name | N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[[4-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]piperazin-1-yl]methyl]benzamide |
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| Synonym | More Synonyms |
| Description | Imatinib Impurity E is the impurity of Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively[1][2][3][4]. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV[5]. |
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| Related Catalog | |
| References |
[4]. Okuda K, et al. ARG tyrosine kinase activity is inhibited by STI571.Blood. 2001 Apr 15;97(8):2440-8. |
| Molecular Formula | C52H48N12O2 |
|---|---|
| Molecular Weight | 873.01700 |
| Exact Mass | 872.40200 |
| PSA | 166.08000 |
| LogP | 9.48480 |
| Hazard Codes | Xi |
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| Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity |
| 1,4-Bis-[4-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]carbamoyl]benzylpiperazine |
| Imatinib Impurity 15 |