Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

Modify Date: 2024-01-02 19:47:26

Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate Structure
Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate structure
Common Name Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
CAS Number 137076-54-1 Molecular Weight 572.734
Density 1.079 Boiling Point 632.1±55.0 °C at 760 mmHg
Molecular Formula C28H52N4O8 Melting Point 129-131 ºC
MSDS N/A Flash Point 336.1±31.5 °C

 Use of Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate


DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging[1].

 Names

Name 2-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
Synonym More Synonyms

  Biological Activity

Description DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging[1].
Related Catalog
References

[1]. Kaneshiro TL, et, al. Synthesis and evaluation of globular Gd-DOTA-monoamide conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolecules. 2008 Oct;9(10):2742-8.

 Chemical & Physical Properties

Density 1.079
Boiling Point 632.1±55.0 °C at 760 mmHg
Melting Point 129-131 ºC
Molecular Formula C28H52N4O8
Molecular Weight 572.734
Flash Point 336.1±31.5 °C
Exact Mass 572.378540
PSA 129.16000
LogP 3.76
Vapour Pressure 0.0±4.0 mmHg at 25°C
Index of Refraction 1.480

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26

 Synthetic Route

 Synonyms

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid Tri-tert-butyl Ester
DOTA-tri-t-Bu-ester
DOTA-Tris(Tbu ester)
DOTA-tris-tert-butyl ester
2-(1,4,7,10-tetraaza-4,7,10-tris(((tert-butyl)-oxycarbonyl)methyl)cyclododecyl)acetic acid
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
DOTA-(t-butyl ester)3-CO2H
TPC-M011
DOTA-tri-tert-butyl-ester
(4,7,10-Tris{2-[(2-methyl-2-propanyl)oxy]-2-oxoethyl}-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid
2-(4,7,10-TRIS(2-TERT-BUTOXY-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECAN-1-YL)ACETIC ACID
[4,7,10-Tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid
1,4,7-tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane
Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
DOTA-(tert-butyl ester)3-CO2H
MFCD02259697
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid
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