Pomolic acid

Modify Date: 2024-01-02 13:06:29

Pomolic acid Structure
Pomolic acid structure
Common Name Pomolic acid
CAS Number 13849-91-7 Molecular Weight 472.700
Density 1.1±0.1 g/cm3 Boiling Point 586.2±50.0 °C at 760 mmHg
Molecular Formula C30H48O4 Melting Point N/A
MSDS N/A Flash Point 322.4±26.6 °C

 Use of Pomolic acid


Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].

 Names

Name pomolic acid
Synonym More Synonyms

 Pomolic acid Biological Activity

Description Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].
Related Catalog
Target

IC50: apoptosis[1]

In Vitro Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation.  Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9[2].
References

[1]. Guimarães LPTP, et al. Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells.Oncol Rep. 2017 Oct;38(4):2525-2534.

[2]. Park JH, et al.Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.Molecules. 2018 Sep 3;23(9). pii: E2236.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 586.2±50.0 °C at 760 mmHg
Molecular Formula C30H48O4
Molecular Weight 472.700
Flash Point 322.4±26.6 °C
Exact Mass 472.355255
PSA 76.66000
LogP 7.40
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.568

 Safety Information

Hazard Codes Xi

 Synonyms

Benthamic acid
3β,19-Dihydroxy-5α-urs-12-en-28-oic acid
Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3β)-
(3β)-3,19-Dihydroxyurs-12-en-28-oic acid
Randialic acid A
3β,19α-Dihydroxyurs-12-ene-28-oic acid
3β,19-Dihydroxyurs-12-en-28-oic acid
(1R,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
Serazide
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