Tormentic acid

Modify Date: 2025-08-25 11:09:08

Use of Tormentic acid

Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties[1][2].

Name	(1R,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Synonym	More Synonyms

Description	Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Tormentic acid inhibits LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages[1]. Tormentic acid suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation[2].
References	[1]. An HJ, et al. Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages. Int Immunopharmacol. 2011 Apr;11(4):504-10. [2]. Wu JB, et al. Tormentic acid, a major component of suspension cells of Eriobotrya japonica, suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation. J Agric Food Chem. 2014 Nov 5;62(44):10717-26.

Density	1.2±0.1 g/cm3
Boiling Point	602.7±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₈O₅
Molecular Weight	488.699
Flash Point	332.3±28.0 °C
Exact Mass	488.350189
PSA	97.99000
LogP	6.21
Vapour Pressure	0.0±3.9 mmHg at 25°C
Index of Refraction	1.580
InChIKey	OXVUXGFZHDKYLS-BLIWDXROSA-N
SMILES	CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1(C)O

Hazard Codes	Xi

Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2α,3β)-

Jacarandic acid

tomentic acid

Tormentic acid

(2α,3β)-2,3,19-Trihydroxyurs-12-en-28-oic acid

Euscaphic acid

2,3,19-trihydroxyurs-12-en-28-oic acid

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Price: ￥3700/5 mg

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