DYRKs-IN-1 hydrochloride
Modify Date: 2024-01-10 21:37:46
DYRKs-IN-1 hydrochloride structure
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Common Name | DYRKs-IN-1 hydrochloride | ||
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| CAS Number | 1386980-55-7 | Molecular Weight | 624.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H31Cl2N7O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DYRKs-IN-1 hydrochlorideDYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2]. |
| Name | DYRKs-IN-1 hydrochloride |
|---|
| Description | DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2]. |
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| Related Catalog | |
| Target |
DYRK1A:5 nM (IC50) DYRK1B:8 nM (IC50) |
| In Vitro | DYRKs-IN-1 hydrochloride (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1]. DYRKs-IN-1 hydrochloride (Example 183) is a potent DYRKs inhibitor[2]. |
| References |
[2]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1. |
| Molecular Formula | C30H31Cl2N7O4 |
|---|---|
| Molecular Weight | 624.52 |