ML252
Modify Date: 2024-04-03 10:32:00
ML252 structure
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Common Name | ML252 | ||
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| CAS Number | 1392494-64-2 | Molecular Weight | 308.41700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H24N2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of ML252ML252 is a selective inhibitor of potassium channel, targeting to KCNQ2 channel (Kv7.2) (IC50=69 nM). ML252 also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively[1][2]. |
| Name | (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide |
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| Description | ML252 is a selective inhibitor of potassium channel, targeting to KCNQ2 channel (Kv7.2) (IC50=69 nM). ML252 also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively[1][2]. |
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| Related Catalog | |
| Target |
CYP1A2:6.1 μM (IC50) CYP2C9:18.9 μM (IC50) CYP2D6:19.9 μM (IC50) CYP3A4:3.9 μM (IC50) |
| In Vitro | ML252 (1 μM；0-48 h) 在大鼠肝脏小体中的内在清除率和随后预测的肝脏清除率分别为 1720 mL/min/kg 和 67.3 mL/min/kg[1]。 ML252 (0.1-0 μM) 在 0.3 μM 开始抑制 CHO-KCNQ2 细胞系的 KCNQ2 电流，在 1 μM 时，完全抑制电流[1]。 ML252 (30 μM; 48 h) 对 CHO 细胞无急性毒性[1]。 |
| In Vivo | ML252 具有不适合口服的代谢稳定性[2]。 ML252 (10 mg/kg，3 mg/mL；腹腔注射；单剂量；1 h 后测定) 在大鼠模型中的 B:P 比值为1.9，大脑绝对水平为 672 nM[1]。 |
| References |
| Molecular Formula | C20H24N2O |
|---|---|
| Molecular Weight | 308.41700 |
| Exact Mass | 308.18900 |
| PSA | 32.34000 |
| LogP | 4.55710 |
| RIDADR | NONH for all modes of transport |
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