Tiotropium bromide hydrate
Tiotropium bromide hydrate structure
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Common Name | Tiotropium bromide hydrate | ||
|---|---|---|---|---|
| CAS Number | 139404-48-1 | Molecular Weight | 490.432 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H24BrNO5S2 | Melting Point | 218-220ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tiotropium bromide hydrateTiotropium Bromide hydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.Target: mAChRTiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against cholinergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) [1]. Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but more rapidly from M2-receptors, thereby giving it a unique kinetic selectivity [2]. |
| Name | Tiotropium Bromide |
|---|---|
| Synonym | More Synonyms |
| Description | Tiotropium Bromide hydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.Target: mAChRTiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against cholinergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) [1]. Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but more rapidly from M2-receptors, thereby giving it a unique kinetic selectivity [2]. |
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| Related Catalog | |
| References |
| Melting Point | 218-220ºC |
|---|---|
| Molecular Formula | C19H24BrNO5S2 |
| Molecular Weight | 490.432 |
| Exact Mass | 489.027924 |
| PSA | 124.77000 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2934999090 |
|
~74%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: BILGIC, Mahmut Patent: US2013/30182 A1, 2013 ; Location in patent: Paragraph 0102 ; |
|
~96%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; GORE, Vinayak Govind; MANOJKUMAR, Bindu; SHINDE, Dattatraya; KOKANE, Dattatrey Patent: WO2011/15884 A1, 2011 ; Location in patent: Page/Page column 16 ; |
|
~85%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: Drug Process Licensing Associates, LLC Patent: US2012/123125 A1, 2012 ; Location in patent: Page/Page column 3 ; |
|
~%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: US2006/246009 A1, ; Page/Page column 4 ; |
|
~%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: WO2011/123077 A1, ; |
|
~%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: WO2011/123077 A1, ; |
|
~%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: WO2013/143510 A1, ; |
|
~%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: US2013/30182 A1, ; |
|
~%
Tiotropium brom... CAS#:139404-48-1 |
| Literature: US2013/30182 A1, ; |
![7-(2,2-dithiophen-2-ylacetoxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide structure](https://image.chemsrc.com/caspic/078/1336913-22-4.png)
![(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 2,2-di(thiophen-2-yl)acetate structure](https://image.chemsrc.com/caspic/116/1336913-21-3.png)
| Precursor 9 | |
|---|---|
| DownStream 0 | |
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 3-Oxa-9-azoniatricyclo[3.3.1.0]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, (1R,2R,4S,5S)-, hydrate (1:1:1) |
| 3-oxa-9-azoniatricyclo[3.3.1.0]nonane, 7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, (1R,2R,4S,5S)-, monohydrate |
| (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide hydrate |
| MFCD00867027 |
| Tiotropium bromide hydrate |
| (1R,2R,4S,5S,7S)-7-{[Hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonanbromidhydrat |
| Tiotropium bromide monohydrate |
| bromure de (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophén-2-yl)acétyl]oxy}-9,9-diméthyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane hydrate |
| (1R,2R,4S,5S,7s)-7-[2-Hydroxy(di-2-thienyl)acetoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide hydrate (1:1:1) |
| Tiotropium bromide xhydrate |
| Tiotropium (bromide hydrate) |