8α-Hydroxyhirsutinolide

Modify Date: 2024-01-09 12:38:04

8α-Hydroxyhirsutinolide Structure
8α-Hydroxyhirsutinolide structure
Common Name 8α-Hydroxyhirsutinolide
CAS Number 1394156-45-6 Molecular Weight 296.32
Density 1.4±0.1 g/cm3 Boiling Point 587.4±50.0 °C at 760 mmHg
Molecular Formula C15H20O6 Melting Point N/A
MSDS N/A Flash Point 222.7±23.6 °C

 Use of 8α-Hydroxyhirsutinolide


8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea[1].

 Names

Name (1R,2E,8S,10R,11S)-8,11-Dihydroxy-6-(hydroxymethyl)-1,10-dimethyl-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-5-one
Synonym More Synonyms

 8α-Hydroxyhirsutinolide Biological Activity

Description 8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea[1].
Related Catalog
References

[1]. Youn UJ, et al. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 587.4±50.0 °C at 760 mmHg
Molecular Formula C15H20O6
Molecular Weight 296.32
Flash Point 222.7±23.6 °C
Exact Mass 296.125977
LogP 0.51
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.610
Storage condition 2-8℃

 Safety Information

Hazard Codes Xi

 Synonyms

(1R,2E,8S,10R,11S)-8,11-Dihydroxy-6-(hydroxymethyl)-1,10-dimethyl-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-5-one
7,10-Epoxycyclodeca[b]furan-2(4H)-one, 5,6,7,8,9,10-hexahydro-4,7-dihydroxy-3-(hydroxymethyl)-6,10-dimethyl-, (4S,6R,7S,10R,11E)-
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