Nithiamide

Modify Date: 2024-01-02 14:48:41

Nithiamide structure	Common Name	Nithiamide
	CAS Number	140-40-9	Molecular Weight	187.17600
	Density	1.598g/cm3	Boiling Point	303.8ºC at 760mmHg
	Molecular Formula	C₅H₅N₃O₃S	Melting Point	263°C (dec.)
	MSDS	Chinese USA	Flash Point	137.5ºC
	Symbol	GHS07	Signal Word	Warning

Use of Nithiamide

Nithiamide is a non-5-nitroimidazole drugs, is a antibiotic used in veterinary.

Name	2-Acetamido-5-nitrothiazole
Synonym	More Synonyms

Description	Nithiamide is a non-5-nitroimidazole drugs, is a antibiotic used in veterinary.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection

Density	1.598g/cm3
Boiling Point	303.8ºC at 760mmHg
Melting Point	263°C (dec.)
Molecular Formula	C₅H₅N₃O₃S
Molecular Weight	187.17600
Flash Point	137.5ºC
Exact Mass	187.00500
PSA	116.05000
LogP	1.60590
Vapour Pressure	0.000911mmHg at 25°C
Index of Refraction	1.666

Nithiamide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ1570000

CHEMICAL NAME :: Thiazole, 2-acetamido-5-nitro-

CAS REGISTRY NUMBER :: 140-40-9

BEILSTEIN REFERENCE NO. :: 0167361

LAST UPDATED :: 199612

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C5-H5-N3-O3-S

MOLECULAR WEIGHT :: 187.19

WISWESSER LINE NOTATION :: T5N CSJ BMV1 DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - turkey

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 200 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,153,1983

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S22-S36/37
RIDADR	NONH for all modes of transport
RTECS	XJ1570000
HS Code	2934100090

5-Nitrothiazol-...

CAS#:121-66-4

Ethanoic anhydride

CAS#:108-24-7

~90%

Nithiamide

CAS#:140-40-9

Literature: Bioorganic and Medicinal Chemistry, , vol. 22, # 5 p. 1626 - 1633

2-acetamidothiazole

CAS#:2719-23-5

Nithiamide

CAS#:140-40-9

Literature: Proceedings - Indian Academy of Sciences, Section A, , # 22 p. 362,376 Yakugaku Zasshi, , vol. 72, p. 1020 Chem.Abstr., , p. 10286 Galenica Acta, , vol. 12, p. 249,252 Takamine Kenkyusho Nenpo, , vol. 8, p. 40 Chem.Abstr., , p. 359

2-Acetamido-5-b...

CAS#:7336-54-1

Nithiamide

CAS#:140-40-9

Literature: Journal of the American Chemical Society, , vol. 71, p. 4007,4009

5-Nitrothiazol-...

CAS#:121-66-4

Nithiamide

CAS#:140-40-9

Literature: Annali di Chimica Applicata, , vol. 38, p. 449,454

2-acetamidothiazole

CAS#:2719-23-5

ethyl nitrate

CAS#:625-58-1

Nithiamide

CAS#:140-40-9

Literature: Annali di Chimica Applicata, , vol. 38, p. 449,454

Ethanoic anhydride

CAS#:108-24-7

thiazol-2-amine...

CAS#:57530-25-3

Nithiamide

CAS#:140-40-9

Literature: Pharmaceutical Chemistry Journal, , vol. 9, # 9 p. 584 - 585 Khimiko-Farmatsevticheskii Zhurnal, , vol. 9, # 9 p. 36 - 37

Precursor 6
CAS#:121-66-4 5-Nitrothiazol-... CAS#:108-24-7 Ethanoic anhydride CAS#:2719-23-5 2-acetamidothiazole CAS#:7336-54-1 2-Acetamido-5-b...
CAS#:625-58-1 ethyl nitrate CAS#:57530-25-3 thiazol-2-amine...
DownStream 1
CAS#:121-66-4 5-Nitrothiazol-...

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Back to the future: oral targeted therapy for RA and other autoimmune diseases.

Nat. Rev. Rheumatol. 9(3) , 173-82, (2013)

The molecular biology revolution coupled with the development of monoclonal antibody technology enabled remarkable progress in rheumatology therapy, comprising an array of highly effective biologic ag...

[The treatment of intra-abdominal abscess].

Klin. Khir. (7) , 32-3, (1998)

The experience of treatment of 18 patients with intraabdominal abscess using the regional laparostomy conduction and introducing nitazol, immobilized on polymethylsiloxane, in the abscess cavity, was ...

[Nitazole--an antimicrobial substance].

Mikrobiol. Z. 60(1) , 83-91, (1998)

The antibacterial activity of protistocide drug nitazole has been revealed for the first time in the 80's at the Laboratory of Clinical Microbiology of the Mechnikov Research Institute of Microbiology...

EINECS 205-414-7

MFCD00022438

N-(5-nitro-1,3-thiazol-2-yl)acetamide

2-Acetamido-5-Nitrothiazole

N-(5-Nitrothiazol-2-yl)acetamide

Nithiamide

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Nithiamide
Price: ￥518.0/1g ￥1868.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Acetamide,N-(5-nitro-2-thiazolyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Nithiamide suppliers

Price: ￥420/100mg

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Nithiamide

Use of Nithiamide

Names

Nithiamide Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles11

Synonyms