Nithiamide

Modify Date: 2024-01-02 14:48:41

Nithiamide Structure
Nithiamide structure
 Common Name Nithiamide
CAS Number 140-40-9 Molecular Weight 187.17600
Density 1.598g/cm3 Boiling Point 303.8ºC at 760mmHg
Molecular Formula C5H5N3O3S Melting Point 263°C (dec.)
MSDS Chinese USA Flash Point 137.5ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Nithiamide


Nithiamide is a non-5-nitroimidazole drugs, is a antibiotic used in veterinary.

 Names

Name 2-Acetamido-5-nitrothiazole
Synonym More Synonyms

 Nithiamide Biological Activity

Description Nithiamide is a non-5-nitroimidazole drugs, is a antibiotic used in veterinary.
Related Catalog

 Chemical & Physical Properties

Density 1.598g/cm3
Boiling Point 303.8ºC at 760mmHg
Melting Point 263°C (dec.)
Molecular Formula C5H5N3O3S
Molecular Weight 187.17600
Flash Point 137.5ºC
Exact Mass 187.00500
PSA 116.05000
LogP 1.60590
Vapour Pressure 0.000911mmHg at 25°C
Index of Refraction 1.666

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ1570000
CHEMICAL NAME :
Thiazole, 2-acetamido-5-nitro-
CAS REGISTRY NUMBER :
140-40-9
BEILSTEIN REFERENCE NO. :
0167361
LAST UPDATED :
199612
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C5-H5-N3-O3-S
MOLECULAR WEIGHT :
187.19
WISWESSER LINE NOTATION :
T5N CSJ BMV1 DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Blood - changes in cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - turkey
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Gene conversion and mitotic recombination
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
200 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,153,1983

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S22-S36/37
RIDADR NONH for all modes of transport
RTECS XJ1570000
HS Code 2934100090

 Synthetic Route

5-Nitrothiazol-2-amine structure

5-Nitrothiazol-...

CAS#:121-66-4

Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7

~90%

Nithiamide Structure

Nithiamide

CAS#:140-40-9

Literature: Bioorganic and Medicinal Chemistry, , vol. 22, # 5 p. 1626 - 1633
2-acetamidothiazole structure

2-acetamidothiazole

CAS#:2719-23-5

~%

Nithiamide Structure

Nithiamide

CAS#:140-40-9

Literature: Proceedings - Indian Academy of Sciences, Section A, , # 22 p. 362,376 Yakugaku Zasshi, , vol. 72, p. 1020 Chem.Abstr., , p. 10286 Galenica Acta, , vol. 12, p. 249,252 Takamine Kenkyusho Nenpo, , vol. 8, p. 40 Chem.Abstr., , p. 359
2-Acetamido-5-bromo-1,3-thiazole structure

2-Acetamido-5-b...

CAS#:7336-54-1

~%

Nithiamide Structure

Nithiamide

CAS#:140-40-9

Literature: Journal of the American Chemical Society, , vol. 71, p. 4007,4009
5-Nitrothiazol-2-amine structure

5-Nitrothiazol-...

CAS#:121-66-4

~%

Nithiamide Structure

Nithiamide

CAS#:140-40-9

Literature: Annali di Chimica Applicata, , vol. 38, p. 449,454
2-acetamidothiazole structure

2-acetamidothiazole

CAS#:2719-23-5

ethyl nitrate structure

ethyl nitrate

CAS#:625-58-1

~%

Nithiamide Structure

Nithiamide

CAS#:140-40-9

Literature: Annali di Chimica Applicata, , vol. 38, p. 449,454
Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7

thiazol-2-amine mononitrate structure

thiazol-2-amine...

CAS#:57530-25-3

~%

Nithiamide Structure

Nithiamide

CAS#:140-40-9

Literature: Pharmaceutical Chemistry Journal, , vol. 9, # 9 p. 584 - 585 Khimiko-Farmatsevticheskii Zhurnal, , vol. 9, # 9 p. 36 - 37

 Customs

HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Articles11

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Back to the future: oral targeted therapy for RA and other autoimmune diseases.

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The molecular biology revolution coupled with the development of monoclonal antibody technology enabled remarkable progress in rheumatology therapy, comprising an array of highly effective biologic ag...

[The treatment of intra-abdominal abscess].

Klin. Khir. (7) , 32-3, (1998)

The experience of treatment of 18 patients with intraabdominal abscess using the regional laparostomy conduction and introducing nitazol, immobilized on polymethylsiloxane, in the abscess cavity, was ...

[Nitazole--an antimicrobial substance].

Mikrobiol. Z. 60(1) , 83-91, (1998)

The antibacterial activity of protistocide drug nitazole has been revealed for the first time in the 80's at the Laboratory of Clinical Microbiology of the Mechnikov Research Institute of Microbiology...

 Synonyms

EINECS 205-414-7
MFCD00022438
N-(5-nitro-1,3-thiazol-2-yl)acetamide
2-Acetamido-5-Nitrothiazole
N-(5-Nitrothiazol-2-yl)acetamide
Nithiamide
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