BMS-906024
Modify Date: 2025-08-25 19:07:45
BMS-906024 structure
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Common Name | BMS-906024 | ||
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| CAS Number | 1401066-79-2 | Molecular Weight | 556.500 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 726.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C26H26F6N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 393.0±32.9 °C | |
Use of BMS-906024BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor[1]. BMS-906024 prevents the activation of all four Notch receptors with a high oral bioavailability with IC50s of 1.6, 0.7, 3.4, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts[2]. |
| Name | (2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide |
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| Synonym | More Synonyms |
| Description | BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor[1]. BMS-906024 prevents the activation of all four Notch receptors with a high oral bioavailability with IC50s of 1.6, 0.7, 3.4, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts[2]. |
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| Related Catalog | |
| Target |
IC50: 1.6 nM (Notch1), 0.7 nM (Notch2), 3.4 nM (Notch3) and 2.9 nM (Notch4)[2] |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 726.3±60.0 °C at 760 mmHg |
| Molecular Formula | C26H26F6N4O3 |
| Molecular Weight | 556.500 |
| Flash Point | 393.0±32.9 °C |
| Exact Mass | 556.190918 |
| PSA | 109.34000 |
| LogP | 2.10 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.558 |
| UNII-DRL23N424R |
| T67 GNVJN IHJ G1 IMVY2XFFFY2XFFFVZ KR &&(2R,3S)-(3S)- Form |
| (2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide |
| BMS-906024 |
| Butanediamide, N-[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)-, (2R,3S)- |
| (2R,3S)-N-[(3S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)succinamide |