Restrictocin
Modify Date: 2024-01-07 09:13:56
Restrictocin structure
|
Common Name | Restrictocin | ||
|---|---|---|---|---|
| CAS Number | 1406-72-0 | Molecular Weight | 355.474 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 577.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H29N3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 303.2±30.1 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of RestrictocinRestrictocin is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| Name | 4-(1-Isobutyl-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)-N,N-dimethyl-4-oxobutanamide |
|---|---|
| Synonym | More Synonyms |
| Description | Restrictocin is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
|---|---|
| Related Catalog |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 577.7±50.0 °C at 760 mmHg |
| Molecular Formula | C21H29N3O2 |
| Molecular Weight | 355.474 |
| Flash Point | 303.2±30.1 °C |
| Exact Mass | 355.225983 |
| LogP | 2.79 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.582 |
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H312-H317-H332-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| RIDADR | NONH for all modes of transport |
| RTECS | VH4725000 |
|
The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
Biochemistry 50(14) , 3004-13, (2011) Restrictocin and related fungal endoribonucleases from the α-sarcin family site-specifically cleave the sarcin/ricin loop (SRL) on the ribosome to inhibit translation and ultimately trigger cell death... |
|
|
Role of individual cysteine residues and disulfide bonds in the structure and function of Aspergillus ribonucleolytic toxin restrictocin.
Biochemistry 38(31) , 10052-8, (1999) Restrictocin, produced by the fungus Aspergillus restrictus, belongs to the group of ribonucleolytic toxins called ribotoxins. It specifically cleaves a single phosphodiester bond in a conserved stem ... |
|
|
Mechanism of specific target recognition and RNA hydrolysis by ribonucleolytic toxin restrictocin.
Biochemistry 40(31) , 9115-24, (2001) Restrictocin, a member of the fungal ribotoxin family, specifically cleaves a single phosphodiester bond in the 28S rRNA and potently inhibits eukaryotic protein synthesis. Residues Tyr47, His49, Glu9... |
| 2H-Pyrido[3,4-b]indole-2-butanamide, 1,3,4,9-tetrahydro-N,N-dimethyl-1-(2-methylpropyl)-γ-oxo- |
| 4-(1-Isobutyl-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)-N,N-dimethyl-4-oxobutanamide |