Verosudil(AR-12286)
Modify Date: 2024-01-08 11:58:54
Verosudil(AR-12286) structure
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Common Name | Verosudil(AR-12286) | ||
|---|---|---|---|---|
| CAS Number | 1414854-42-4 | Molecular Weight | 327.401 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 625.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H17N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 332.1±31.5 °C | |
Use of Verosudil(AR-12286)Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2]. |
| Name | verosudil |
|---|---|
| Synonym | More Synonyms |
| Description | Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2]. |
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| Related Catalog | |
| Target |
ROCK1:2 nM (Ki) ROCK2:2 nM (Ki) PKA:69 nM (Ki) MRCKA:28 nM (Ki) CAM2A:5855 nM (Ki) PKC theta:9322 nM (Ki) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 625.5±55.0 °C at 760 mmHg |
| Molecular Formula | C17H17N3O2S |
| Molecular Weight | 327.401 |
| Flash Point | 332.1±31.5 °C |
| Exact Mass | 327.104156 |
| LogP | 0.84 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.666 |
| verosudil |
| UNII:MAF34143WM |
| 2-(Dimethylamino)-N-(1-oxo-1,2-dihydro-6-isoquinolinyl)-2-(3-thienyl)acetamide |
| 3-Thiopheneacetamide, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-α-(dimethylamino)- |
| UNII: MAF34143WM |
| AR-12286 |
| MAF34143WM |