Vazegepant hydrochloride

Modify Date: 2024-01-05 19:15:45

Vazegepant hydrochloride Structure
Vazegepant hydrochloride structure
Common Name Vazegepant hydrochloride
CAS Number 1414976-20-7 Molecular Weight 675.26
Density N/A Boiling Point N/A
Molecular Formula C36H47ClN8O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Vazegepant hydrochloride


Vazegepant (BHV-3500) hydrochloride is a highly affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation[1][2][3].

 Names

Name Vazegepant hydrochloride

 Vazegepant hydrochloride Biological Activity

Description Vazegepant (BHV-3500) hydrochloride is a highly affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation[1][2][3].
Related Catalog
Target

Ki: 0.023 nM (hCGRP)[3]

References

[1]. Moreno-Ajona D, et al. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?. Curr Opin Neurol. 2020;33(3):309-315.

[2]. Mehta PP, et al. Novel and Evolving Therapies for COVID-19 Related Pulmonary Complications. Am J Med Sci. 2021;361(5):557-566.

[3]. Moreno-Ajona D, Pérez-Rodríguez A, Goadsby PJ. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?. Curr Opin Neurol. 2020;33(3):309-315.

 Chemical & Physical Properties

Molecular Formula C36H47ClN8O3
Molecular Weight 675.26
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