Dynole 2−24

Modify Date: 2025-08-25 18:00:02

Dynole 2−24 Structure
Dynole 2−24 structure
Common Name Dynole 2−24
CAS Number 1416313-72-8 Molecular Weight 371.60
Density N/A Boiling Point N/A
Molecular Formula C24H41N3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Dynole 2−24


Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

 Names

Name Dynole 2−24

 Dynole 2−24 Biological Activity

Description Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis
Related Catalog
References

[1]. Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56(1):46-59.

 Chemical & Physical Properties

Molecular Formula C24H41N3
Molecular Weight 371.60

 Safety Information

Hazard Codes Xi
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