IM156

Modify Date: 2024-01-21 12:02:51

IM156 Structure
IM156 structure
 Common Name IM156
CAS Number 1422365-93-2 Molecular Weight 315.29
Density 1.4±0.1 g/cm3 Boiling Point 337.2±52.0 °C at 760 mmHg
Molecular Formula C13H16F3N5O Melting Point N/A
MSDS N/A Flash Point 157.8±30.7 °C

 Use of IM156


Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus[1][5].

 Names

Name N-{N-[4-(Trifluoromethoxy)phenyl]carbamimidoyl}-1-pyrrolidinecarboximidamide
Synonym More Synonyms

 IM156 Biological Activity

Description Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus[1][5].
Related Catalog
Target

oxidative phosphorylation (OXPHOS)[1]

References

[1]. Willette RN, et al. Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis. J Pharmacol Exp Ther. 2021 Nov;379(3):290-300.  

[2]. Shim JS, Kim EJ, Lee LE, Kim JY, Cho Y, Kim H, Kim J, Jang SH, Son J, Cheong JH, Kim A, Lim BJ, Ha SJ, Song JJ, Kim BS. The oxidative phosphorylation inhibitor IM156 suppresses B-cell activation by regulating mitochondrial membrane potential and contributes to the mitigation of systemic lupus erythematosus. Kidney Int. 2023 Feb;103(2):343-356.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 337.2±52.0 °C at 760 mmHg
Molecular Formula C13H16F3N5O
Molecular Weight 315.29
Flash Point 157.8±30.7 °C
Exact Mass 315.130707
LogP 0.96
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.578

 Safety Information

Hazard Codes Xn

 Synonyms

N-{N-[4-(Trifluoromethoxy)phenyl]carbamimidoyl}-1-pyrrolidinecarboximidamide
1-Pyrrolidinecarboximidamide, N-[imino[[4-(trifluoromethoxy)phenyl]amino]methyl]-
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Related Compounds: More...
IM156
1422365-94-3
4-(3,4-Diethoxyphenyl)-3-(2-hydroxy-3,5-dimethylphenyl)-5-(pyridin-3-ylmethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879964-72-4
4-(4-Bromophenyl)-3-(2-hydroxy-3,5-dimethylphenyl)-5-(pyridin-3-ylmethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879964-88-2
3-(2-Hydroxy-3,5-dimethylphenyl)-4-(4-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879964-97-3
4-(3-Chlorophenyl)-3-(2-hydroxy-3,5-dimethylphenyl)-5-(pyridin-3-ylmethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879965-05-6
4-(2-Fluorophenyl)-3-(2-hydroxy-3,5-dimethylphenyl)-5-(pyridin-3-ylmethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879965-13-6
3-(2-Hydroxyphenyl)-4-(4-methylsulfanylphenyl)-5-(3-propan-2-yloxypropyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879933-95-6
3-(2-Hydroxyphenyl)-4-(3-methoxyphenyl)-5-(oxolan-2-ylmethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879934-11-9
3-(2-Hydroxyphenyl)-4-(3-hydroxyphenyl)-5-(oxolan-2-ylmethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879934-59-5
4-(3,4-Dimethoxyphenyl)-3-(2-hydroxyphenyl)-5-(2-methoxyethyl)-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879951-26-5
3-(2-Hydroxyphenyl)-4-(4-methylsulfanylphenyl)-5-propyl-1,2,3,3a,4,6a-hexahydropyrrolo[3,4-c]pyrazol-6-one
879957-63-8
Chemsrc provides IM156(CAS#:1422365-93-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of IM156 are included as well.>> amp version: IM156

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