Shizukaol B
Modify Date: 2025-08-24 22:46:24
Shizukaol B structure
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Common Name | Shizukaol B | ||
|---|---|---|---|---|
| CAS Number | 142279-40-1 | Molecular Weight | 732.77000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H44O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Shizukaol BShizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1]. |
| Name | shizukaol B |
|---|
| Description | Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1]. |
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| Related Catalog | |
| Target |
COX-2 iNOS IL-1β |
| In Vitro | Shizukaol B (25 μM; 0-60 min) 抑制 LPS (1 μg/mL; 0-60 min) 介导的 c-Jun N 末端激酶 1/2 (JNK) 激活，不影响 ERK1/2 或 p38 磷酸化[1]。 Shizukaol B (12.5-50 μM; 4 h) 抑制 LPS 诱导 (1 μg/mL; 24 h) 的 NO 生成，抑制 iNOS 和 COX-2 的表达[1]。 |
| References |
| Molecular Formula | C40H44O13 |
|---|---|
| Molecular Weight | 732.77000 |
| Exact Mass | 732.27800 |
| PSA | 189.03000 |
| LogP | 2.37710 |
| InChIKey | NCEFZVURTXZBJM-UHFFFAOYSA-N |
| SMILES | COC(=O)C(C)=C1C(=O)C(O)C2(C)C3=C(CC4C5(OC(=O)C6=C5CC5C(O)(COC(=O)C(C)=CCOC(=O)CCC(=O)OC6)C6CC6C54C)C13)C1CC12 |